Publications

 26. Loprinzi PD, Firth E, Edwards MK, Sng E, Ashpole NM. (2018) The Effects of Exercise on Memory Function Among Young to Middle-Aged Adults: Systematic Review and Recommendations for Future Research. American Journal of Health Promotion. Mar;32(3):691-704.

25. Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE. (2017) IGF-1 has Sexually Dimorphic, Pleiotropic, and Time-Dependent Effects on Healthspan, Pathology, and Lifespan. Geroscience. Apr; 39(2):129-145.

24. Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole NM, Gautam T, Giles CB, Wren JD, Sonntag WE, Csiszar A, Ungvari Z. (2017) Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. Jun; 16(3): 469-479.

23. Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G. (2016) The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. Journal of Biological Chemistry. Nov 11;291(46):23895-23905.

22. Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. (2016) Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age. Aug;38(4):273-289.

21. Tarantini S, Giles CB, Wren JD, Ashpole NM, Valcarcel-Ares MN, Wei JY, Sonntag WE, Ungvari Z, Csiszar A. (2016) IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age. Aug;38(4):239-258.

20. Ashpole NM, Herron JC, Estep PN, Logan S, Hodges EL, Yabluchanskiy A, Humphrey MB, Sonntag WE (2016). Differential effects of IGF-1 deficiency during  the lifespan on structural and biomechanical properties in the tibia of aged mice. Age. Apr;38(2):38

19. Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag, WE (2016). IGF-1 regulates vertebral bone aging through sex-specific and time-dependent mechanisms. Journal of Bone and Mineral Research. Feb;31(2):443-54.

18. Toth P, Tarantini S, Ashpole NM, Tucsek Z, Milne GL, Valcarcel-Ares NM, Menyhart A, Farkas E, Sonntag WE, Csiszar A, Ungvari Z (2015) IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebomicrovascular aging. Aging Cell. Epub July 14.

17. Le WH, Xu X, Ashpole NM, Hudmon A, Kulkarni PM, Thakur GH, Lai YY, Hohmann AG. (2015) Small molecule inhibitors of PSD-95-nNOS protein-protein interactions as novel analgesics. Neuropharmacology. Dec;14(6):1034-44.

16. Springo Z, Toth P, Tarantini S, Ashpole NM, Tucsek Z, Sonntag WE, Csiszar A, Koller  A,  Ungvari  ZI.  (2015)  Aging  impairs  myogenic  adaptation  to        pulsatile contractility in mouse cerebral arteries. Journal of Cerebral Blood Flow and Metabolism. March 31: 35(4):527-30.

15. Ashpole NM, Sanders JE, Hodges EL, Yan H, Sonntag WE (2014). Growth hormone, insulin-like growth factor-1 and the aging brain. Experimental Gerontology. Aug: 68:76-81.

14. Yan H, Mitschelen M, Toth P, Ashpole NM, Farley JA, Hodges EL, Warrington JP, Han S, Fung KM, Csiszar A, Ungvari Z, Sonntag WE (2014). Endothelin-1-induced focal cerebral ischemia in Growth Hormone/IGF-1 deficient Lewis Dwarf Rat. Journal of Gerontology: Biological Sciences and Medical Sciences Nov;69(11):1353-62.

13. Ashpole NM, Warrington JP, Mitschelen MC, Yan H, Sosnowska D, Gautam T, Farley JA, Csiszar A, Ungvari ZI, Sonntag WE (2014). Systemic influences contribute to prolonged vascular rarefaction following brain irradiation: a role for endothelial progenitor cells. American Journal of Physiology – Heart and Circulatory Physiology, Sep 15;307(6):H858-68.

12. Toth P, Tarantini S, Tucsek Z, Ashpole NM, Sosnowska D, Guatam T, Ballabh P, Koller A, Sonntag WE, Csiszar A, Unvgari Z (2014). Resveratrol treatment rescues neurovascular coupling in aged mice:role of improved cerebromicrovascular endothelial function and down-regulation of NADPH oxidase. American Journal of Physiology - Heart and Circulatory Physiology, 306(3):H299-308.

11. Warrington JP, Ashpole NM, Csiszar A, Lee YW, Ungvari Z, Sonntag WE. (2013). Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications. Journal of Vascular Research, 50(6):445-457.

10. Sonntag WE, Deak F, Ashpole NM, Toth P, Csiszar A, Freeman W, Ungvari Z. (2013) Insulin-like growth factor-1 in CNS and cerebrovascular aging. Frontiers in Aging Neuroscience,5:27.

9. Ashpole NM, Chawla AR, Martin MP, Brustovetsky T, Brustovetsky N, Hudmon, A. (2013) Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. Journal of Biological Chemistry, 288(20):14599-611.

8.  Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins  TR, and Shou W. (2012) The human Nav1.5 F1486 deletion associated with Long QT Syndrome leads to impaired sodium channel inactivation and reduced Lidocaine sensitivity. Journal of Physiology, 590(Pt 20):5123-39.

7. Ashpole NM*, Herren A*, Ginsburg K, Brogan J, Johnson D, Cummins T, Bers D,  and Hudmon A. (2012). Mechanisms underlying Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulation of cardiac sodium channel Nav1.5 gating. Journal of Biological Chemistry 287(24):19856-69.

6. Ashpole NM, Song W, Brustovetsky T, Engelman E, Brustovetsky N, Cummins T, Hudmon A. (2012) Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability. Journal of Biological Chemistry, 287(11):8495-506.

5. Brittain J, Chen L, Broustovetsky T, Gao X,  Ashpole NM, Wilson S, Hudmon A,  White F, Brustovetsky N, Chen J, Khanna R. (2011). Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP-2). Journal of Biological Chemistry. Oct 28;286(43):37778-92.

4. Coultrap S, Vest R, Ashpole NM, Hudmon A, and Bayer KU. (2011). CaMKII and cerebral ischemia. Acta Pharmacologica Sinica, 32 (7):861-72.

3. Brittain J, Duarte D, Wilson S, Zhu W, Ballard C, Johnson P, Liu N, Xiong W, Ripsch M, Wang Y, Fehrenbacher J, Fitz S, Khanna M, Park C, Schmutzler B, Cheon B,  Due M, Brustovetsky T, Ashpole NM, Hudmon A, Meroueh S, Hingtgen C, Brustovetsky N, Ji R, Hurley J, Jin X, Shekhar A, Xu XM, Oxford G, Vasko M, White F,  Khanna  R.  (2011).  Suppression  of  inflammatory  and  neuropathic  pain       by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. Nature Medicine, 17(7):822-9.

2. Li L, Khanna M, Jo I, Wang F, Ashpole NM, Hudmon A, and Meroueh S. (2011). Target-specific support vector machine scoring in structure-based virtual screening: computational validation, in vitro testing in kinases, and effects on lung cancer cell proliferation. Journal of Chemical Information and Modeling, 51(4):755-9.

1. Ashpole NM and Hudmon A. (2011). Excitotoxic neuroprotection and vulnerability  with CaMKII inhibition. Molecular and Cellular Neuroscience, 46(4):720-30.